【预告】学术报告——复杂体系中分子相互作用的NMR研究—挑战与应对

作者:   更新时间:2015-05-18

报告人:刘买利 研究员(武汉物数所)

   间:2015-05-20 (周三) 下午 15:00-16:00

   点:科学会堂二楼会议室

 

报告简介:

Study of drug-biomolecular interaction is crucial for understanding the function and mechanism of drugs and biomolecules. Suppressing the intense water signal and resolving severe overlapped resonances are the two major challenges for the direct NMR study of bio-molecular interaction in complex systems. We have developed a number of NMR methods for high efficient suppression of the water signals and for spectral separation by utilizing multiplicity editing (MAXY), self-diffusion and relaxation weighting (DECOSY, DIRE), without chemical or physical disturbance of the samples. These enable us to directly study the drug-biomolecular interaction in complex samples. Some examples would be shown. To quantitatively evaluate effect of metabolic diversity on the interaction, we proposed an NMR based diversity index and interaction index. The results indicated that the two indexes are highly correlated and could be used to predict the interaction.

 

报告人简介:

刘买利,中科院武汉物数所研究员,波谱与原子分子物理国家重点实验室主任。中科院百人计划入选者,国家杰出青年科学基金获得者。1996年获得英国伦敦大学Birkbeck学院化学系博士学位。199610月起在中国科学院武汉物数所做博士后,19985月博士后出站留所工作。主要从事生物核磁共振(NMR)波谱方法和应用研究。研究兴趣包括高效NMR方法、技术与仪器开发,药物与蛋白质相互作及其动态过程的NMR研究。在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Anal. Chem.等国内外杂志上发表多篇SCI论文。现担任中国物理学会理事、波谱学专业委员会副主任,及多个杂志主编或编辑。国家蛋白质科学”重大研究计划“蛋白质结构的核磁共振测定新技术与新方法的研究”首席科学家。